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Regular reassessment of the risk-benefit balance ensures that therapy remains appropriate as patients' clinical circumstances evolve

Abstract Neurodegenerative diseases represent a major global cause of mortality and disability

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For the newer GLP-1 medications, it would be useful to look at whether there are genetic variants, like the variants in PAM, that explain poor responders to their medications. For now, the mechanism driving GLP-1 resistance remains unresolved, but it is likely complex and multifactorial, Gloyn said

All PCD patients received daily oral L-carnitine supplementation and were monitored in an outpatient setting with regular blood carnitine measurements