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The single most important distinction: Multi-molecule combination (two peptides, one vial): CagriSema = cagrilintide (amylin analog) + semaglutide (GLP-1 agonist) Multi-target single molecule (one peptide, multiple receptors): Tirzepatide = one molecule activating GLP-1 + GIP receptors (dual agonist) Retatrutide = one molecule activating GLP-1 + GIP + glucagon receptors (triple agonist) So CagriSema is a blend

In humans, GLP-1 inhibits meal-induced gastrointestinal motility via vagal pathways 13

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Keep your medication away from direct sunlight, protect pens with their caps on, and avoid leaving them in hot vehicles, as temperatures above 30C can degrade the active ingredient