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Other medications may compound risk, including estrogen-containing hormonal therapies, fibrate lipid-lowering drugs, and certain antibiotics like ceftriaxone

Head-to-head studies demonstrated tirzepatides 20.2% weight loss versus semaglutides 13.7%, a difference of nearly 17 pounds in average patients

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Experimental models include isolated perfused hearts (Langendorff), ex vivo working heart preparations, in vivo echocardiography with metabolic phenotyping, transgenic models affecting carnitine metabolism (OCTN2 knockout, CPT-I variants), and large animal models of myocardial infarction

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