Hereditary Breast Cancer: Comprehensive Risk Assessment and Prevention Strategies
Discussion This study demonstrated that metformin exerts its glucose-lowering effects primarily by modulating intestinal glucose handling through increased glucose uptake and excretion in the distal intestine, specifically the ileum and colon
Until recently, several independent investigations identified SLC25A39 as the mitochondrial transporter regulating GSH uptake [29, 30]
The first group includes the multidrug resistant protein family (MRP) which acts as cotransporters of GSH 7 coupled to the extrusion of an OA (organic anion) and requires the use of energy
While significant breakthroughs have been achieved in multimodal modulation of mitochondrial biogenesis, mitophagy, and dynamics, persisting challenges include incomplete elucidation of molecular regulatory networks and genetic foundations, limitations of single-pathway intervention strategies in achieving multi-target coordination, and technical barriers imposed by the selective permeability of the blood-brain barrier (BBB) that hinder clinical translation of mitochondrial-targeted therapies (Meng et al., 2024)
