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Harnessing cerebrospinal fluid circulation for drug delivery to brain tissues

Your intestines are lined with a thin, living barrier

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Dose and route heterogeneity: animal studies use very variable doses (from 10 nanograms to 10 micrograms per kg) and different routes (intraperitoneal, subcutaneous, intravenous, oral), which complicates comparisons between protocols and establishing a clear dose-response relationship

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