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While melatonin has a direct effect on oxidative stress by scavenging ROS and RNS (5), its metabolites (product of its degradation) are also active and act indirectly by inducing the production of anti-oxidative enzymes and lowering the synthesis of pro-oxidative molecules (6) leading to an overall reduction of oxidative stress

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For example, Ozempics FDA label was expanded in September 2023, shortly after the first lawsuits were filed, to include ileus as a possible gastrointestinal disorder

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