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Mild cramping, early fullness or post-meal discomfort is expected early on in treatment or after dose increases and tends to improve with time

Vitamin B6 (pyridoxine HCl) Vitamin B6 acts as a cofactor for enzymes involved in amino acid metabolism and neurotransmitter production

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It works on the brain's appetite centers, so hunger eases and you feel full sooner, which makes a calorie deficit far easier to hold

Also, both systolic and diastolic dysfunction stemming from the interplay between atherosclerotic coronary disease and diabetic cardiomyopathy are associated with the underlying pathophysiology of HF in patients with T2DM [45, 46]