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Shishido [24] first reported GST in the bacterium Escherichia coli ( E

The interconversion stage of the pentose phosphate pathway In cells with active nucleic acid synthesis, ribulose-5-phosphate from the 6-phosphoglucose dehydrogenase reaction is isomerized to ribose-5-phosphate for synthesis of ribo- and deoxyribonucleotides for RNA and DNA ( Fig

Nonetheless, the conclusions from these different studies raise the question of which, if any, redox couples are directly leading to cell death, i.e., is oxidation of thioredoxins or glutathione important, or are both perhaps simply markers of NADPH depletion