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Emerging nanotechnology approaches, including polymeric nanoparticles and lipid-based delivery systems, show promise in enhancing SFN stability, prolonging circulation time, and improving tumor-specific delivery ( Furthermore, the optimal timing and sequencing of SFN administration in combination therapies require careful consideration

Too much folate can cause nausea, loss of appetite, confusion, irritability, and changes in sleep

599 The balance between Th17 and Treg cells is critical for regulating inflammatory processes and shaping the immune microenvironment, which may synergistically promote liver regeneration

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