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SIRT1 activating compounds reduce oxidative stress mediated neuronal loss in viral induced CNS demyelinating disease

Inflammatory mediators exert toxic effects of oxidative stress on human spermatozoa

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However, if the purpose of the drug is to be taken up by the liver, then first-pass metabolism may be irrelevant (the drug is still metabolized into hepatic glutathione, which is what matters)

Nat Neurosci 20:136144