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1 Nevertheless, Grx1 has been identified as the primary reductant of OxyR, and so its induction during H 2 O 2 stress may provide a quick way to turn off the response once H 2 O 2 levels decline ( In a recent study Winterbourn and colleagues observed that H 2 O 2 rapidly oxidizes the active-site cysteine of mammalian glyceraldehyde-3-phosphate dehydrogenase (GAPDH), specifically when solution levels of carbon dioxide are high

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2011;342:d2218

Campos PMBGM, Franco RSB, Kakuda L, Cadioli GF, D Angelo Costa GM