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Takeuchi Y, Nishikawa H

The combination therapy of SAHA (40 mg/kg, intraperitoneal injection every 3 days) and B7x neutralizing antibody (200 g/mouse, intraperitoneal injection every 2 days) significantly delayed tumor growth, with a tumor inhibition rate of 80.6%, and significantly increased the infiltration of CD8 + and CD4 + T cells in the tumor microenvironment (67)

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Incretin-based peptides exert their effect through G-protein-coupled receptors, the receptors for glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), and glucagon peptide hormones are important regulators of insulin secretion and energy metabolism