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Ensure adequate protein intake (at least 0.8 grams per pound of body weight), prioritize sleep, and avoid dramatic calorie restriction during the transition

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Key Efficacy Comparison Year 1 Outcomes: For chronic weight management in adults without diabetes, tirzepatide 15 mg achieved a mean 22.5% total body weight reduction in SURMOUNT-1 (N Engl J Med, 2022), while semaglutide 2.4 mg delivered approximately 15% in the STEP program

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A schematic representation of the distribution of GLP-1R neurons throughout the mouse brain is given in Figure 2

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Mracsko E, Veltkamp R

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Failing to document comorbidities

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