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Structural superposition of apo and DPA-bound Pa DHDPR revealed that the two conformations were highly similar, with a root-mean-square deviation of 0.54 (over 244 C atoms) (Fig

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[23] [24] Naltrexone/bupropion (Mysimba) is a licensed oral anti-obesity medicine combining an opioid antagonist with a dopamine and noradrenaline reuptake inhibitor