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Signs of intramuscular injection include deeper, aching pain at the injection site, more soreness than usual lasting hours to days, bruising, faster onset of appetite suppression, and more intense initial side effects

Your body absorbs the medication just as well whether you inject it into your abdomen, thigh, or upper armso, all three injection sites are equally effective

Postgrad Med 134(1):1419

The leading drugs in this category are Mounjaro (tirzepatide), Ozempic (semaglutide), and Rybelsus, which is the oral form of semaglutide

Dualincretins like Tirzepatide show the highest average weightloss percentages, and weekly semaglutide offers a strong middle ground with convenient dosing