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for 4 weeks, has also shown benefit alongside pregabalin (a drug commonly used for neuropathic pain), but as this was an uncontrolled trial the contribution B12 made to the improvements cannot be established

Ziegelmann MJ, Heslop D, Houlihan M, Bajic P, Helo S, Trost L, et al

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In a subsequent mechanistic study, they found that MET first activated the MAPK signaling pathway, followed by the activation of the downstream NF-B-mediated p65 transcription factor, which interacted with the proximal region of the PD-L1 promoter to promote PD-L1 expression [133]

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