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Although it has been used as a supplement for decades, the evidence continues to mount
King GL
Mitochondrial dysfunction can result in the production of excessive amounts of superoxide, causing extensive cell damage and death
In addition, it can also activate the UCP1 protein in brown adipose tissue (BAT), increase heat production, and achieve a transition from "energy wasting" metabolism (such as shivering heat production) to "efficient utilization" metabolism
The connections are multiple and complex, but one practical takeaway is that a patient with type 1 diabetes, with hypothyroidism, or on long-term levothyroxine at an excessive dose is at elevated risk for bone loss and should be screened accordingly
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