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CYP2E1 is involved in the conversion of acetone to acetol which is then converted to methylglyoxal, both of which can participate in gluconeogenesis

doi:10.1016/j.parkreldis.2014.02.016 172

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Due to their high rate constant and high abundance, Prx are thought to be responsible for scavenging nanomolar concentrations of H 2 O 2 associated with redox signaling, while Gpx are likely important at higher intracellular concentrations, buffering high ROS levels to avoid cell damage and stress signaling response (Sena and Chandel, 2012)

Furthermore, the accumulation of metabolic byproductssuch as ammonia from urease activitymay induce localized toxicity