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CagA is a marker for the cag pathogenicity island, including the genes necessary for inflammation enhancement caused by pathogenic strains

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The prevalence of vitamin B12 deficiency is particularly elevated among patients with T2D, with studies demonstrating that up to 64% of those with DPN exhibit altered (low or borderline) vitamin B12 levels compared with only 17% of patients without neuropathy

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Emerging concerns include thyroid risks, progression of diabetic retinopathy, and loss of lean muscle mass with rapid weight reduction