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Bone marrow mesenchymal stem cells (BMSCs) can differentiate into various cell types, including osteoblasts and chondrocytes

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Nrf2-regulated glutathione recycling independent of biosynthesis is critical for cell survival during oxidative stress

It is therefore part of a group of rare metabolic diseases that we will not discuss in this study

Adherence to mitochondrial proteins, especially in the setting of GSH depletion, is important because mitochondrial protein binding depletes native antioxidant functions and also alters the mitochondrial ATP-synthase -subunit, leading to ineffective ATP production