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The residues that coordinate Na + are unchanged in position, however the density for Na + is slightly weaker, and there is no density for the axial (basal) water molecule as described for the occluded conformation
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Nat Commun 17 , 181 (2026)
Therefore, only ACC1 isoform is expressed in tumor cells under acidosis to produce malonyl-CoA as a substrate for FA synthesis
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