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Metformin, a first-line T2DM treatment, affects the gastrointestinal tract by altering glucose uptake, GLP-1 secretion, gut microbiota, and immune response [33, 34], but it rarely causes bowel obstruction

They are usually caused by increased pressure from straining during bowel movements, pregnancy, or being overweight

Knowing what to expect at each stage helps distinguish between a genuine problem and normal fluctuations in progress

Furthermore, no undesirable or safety issues have been identified so far as a result of offtarget impacts of DPP4is on other endogenous substrates

Daniel Chille, integrative and functional medicine expert and founder of TBD Fit, to break down the science of recovery, performance, and long-term healthfrom elite athletes to everyday high performers