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Relaxation of glycemic targets for only a short period of time may restore hypoglycemia awareness, which may allow for resumption of somewhat tighter targets

Some experiments even show an increase in body weight and fat, which contradicts marketing claims

10.1016/j.physbeh.2010.03.019 55 HeppnerK

Disqualifying conditions include a history of Diabetes, Kidney Disease, Gallbladder Disease, Pancreatitis, Medullary Thyroid Carcinoma, Multiple Endocrine Neoplasia Syndrome Type 2, Thyroid Nodule that has not been evaluated, Pregnant or Breastfeeding Medical studies report patients losing 15-20% of their body weight on average after one year

These differences mean that semaglutide safety data cannot be automatically applied to tirzepatide and vice versa