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12.3 Pharmacokinetics Semaglutide estimated mean steady-state concentration was 6.7 nmol/L and 14.6 nmol/L following once daily oral administration of 7 mg and 14 mg of RYBELSUS (formulation R1), respectively, in patients with type 2 diabetes mellitus

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By activating GIP receptors, tirzepatide may enhance insulin secretion and potentially improve insulin sensitivity and fat metabolism

Patients with impaired liver or kidney function need extra care, especially when using tirzepatide, which contains benzyl alcohol and may increase the risk of metabolic acidosis