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Lifestyle is still required for long-term success: Whether youre on GLP-1s alone, HRT alone, both, or neither, the fundamentals still determine your results: Resistance training 2-4x weekly High protein intake daily Adequate sleep (7-9 hours) Stress management Sustainable calorie deficit Medications can make these things easier to achieve, but they dont replace them

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Updated February 2026 GLP-1 Drugs and Mental Health: What the Evidence Actually Shows The FDA cleared GLP-1 drugs of psychiatric risk after reviewing 91 trials