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The pathway in mammals is unique using protein-bound lysine that is enzymatically methylated to form trimethyllysine as a post-translational modification of protein synthesis [6]

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Notably, targeting glycolysis represents a promising approach to induce these alternative PCD pathways by promoting the accumulation of ROS and suppressing the generation of Nnicotinamide adenine dinucleotide phosphate (NADPH), thereby providing a rationale for combination therapies in cancer treatment [143]