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Compared to wild-type cells, IRE1-null cells have significantly elevated GSH levels, indicating that the resistance to ferroptosis correlates with altered GSH metabolism in IRE1-deficient cells (Fig
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The cytotoxicity of As 2 O 3 occurred through the generation of reactive oxygen species (ROS), thus inhibiting radical scavenging systems would enhance the therapeutic efficacy of As 2 O 3 provided that normal cells were relatively resistant to such a measure
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