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In white adipose tissue, blocking NNMT elevated resting calorie burn, decreased adiposity, and improved insulin sensitivity in rodent models, independent of diet or activity changes (Kraus et al., Nature Medicine )

Contraindications include pregnancy or breastfeeding, active or suspected cancer, and severe liver or kidney disease

Vitamin B12 deficiency is believed to be one of the most common nutrient deficiencies in the world

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