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Chronic inflammatory response Long-term accumulation of platinum in multiple tissues can induce the generation of a large amount of ROS, promote the sustained release of pro-inflammatory cytokines such as TNF-, IL-6, and IL-1, and form a systemic chronic low-grade inflammatory microenvironment, which is the core driving mechanism of CRF (Bower and Lamkin 2013)

Der Grund liegt in den Bioverfgbarkeitsdaten: Bei intramuskulrer-Injektion landet in Tiermodellen etwa 1419 % (Ratte) bis 4551 % (Hund) der Dosis im Blutkreislauf

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However, it is known that CuO-NPs can exhibit toxicity in rats when administrated orally into 1000 mg/kg for 28 days and result in ROS accumulation

Comparable treatments can cost $300$600 per session