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Similar findings were observed in an ischemia/reperfusion rat forebrain injury, in which chronic trimetazidine (alone or with progesterone) alleviated SOD and glutathione decrease while preventing malondialdehyde and lipid peroxidase increase [181]

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This can lead to the depletion of glutathione, further compromising the body's ability to detoxify toxins and heavy metals

Conversely, broad receptor distribution across multiple cell types (GHK-Cu affecting many cells through gene regulation) provides comprehensive protection for multi-factorial diseases

Without authorised widespread use and systematic surveillance, the absence of reports cannot establish safety