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Low magnesium intake is common, and intracellular magnesium levels have been shown to diminish with aging while blood levels remain stable, making it difficult to detect deficiency

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Payers are signaling willingness to reimburse premium-priced multi-agonists if cardiovascular or renal benefits materialize, a possibility under investigation in ongoing SURMOUNT-5 and TRIUMPH-2 outcome studies

In patients with type 2 diabetes - characterized by insulin resistance and insufficient insulin production - regulation is impaired, leading to chronic hyperglycemia