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While most individuals obtain sufficient amounts of vitamin B12 through their diet, some individuals may require supplementation due to certain health conditions or lifestyle choices that can lead to vitamin B12 deficiency

Functionally all of these phenotypes are characterised by loss of several homoeostatic molecules, which decreases neuronal support and neuroprotection ultimately resulting in neuronal death

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Guidance will need periodic revision as new evidence emerges

Studies of ERAD indicate that it maintains the integrity and functionality of ER-resident or cytoplasmic proteins in response to various stimuli under both physiological and pathophysiological conditions