GLP-1 receptor agonists and the dual agonist tirzepatide modulate appetite, satiety, and gastric emptying, with evidence from STEP (NEJM 2021), SURMOUNT (NEJM 2022), and SURMOUNT-OSA (NEJM 2024)
GHK-Cu is a complex of copper and glycyl-l-histidyl-l-lysine (GHK), a peptide present in human plasma, saliva, and urine that decreases in concentration as we age
Sitagliptin and saxagliptin are among the usually endorsed DPP-4 inhibitors, offering an elective way to deal with improving endogenous it levels
Last, a competitive inhibitor, short peptide based on the sequence of PD-L1 has been shown to be effectively block palmitoylation of PD-L1 inducing its lysosomal clearance (185)
Many people eating less on GLP-1 medications unintentionally reduce their protein intake