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Careful dose adjustment is often needed

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However, it is noted that the clinical outcome of ACI is still variable (Andriolo et al., 2017), and the reasons have not been fully demonstrated

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Both AgRP and NPY axons that co-localize GABA project onto POMC expressing cells in the ARC and the AgRP-stimulated release of GABA results in inhibition of the activity of the POMC neurons, an effect also seen with NPY

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