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Blends of polyphenolsincluding resveratrol and grape juicehave been shown to reduce amyloid neuropathology and improve cognitive deficits in animal models (406)

Importantly, brain endothelial cells present very low rates of vesicle trafficking, limiting the transcytosis transport further contributing to a functional BBB [5]

Furthermore, the authors reported that the MCF-7 breast cancer cell line shows an E2-dependent increase in its survival rate, which is abrogated by pre-treating them with the anti-estrogenic compounds ICI-182, 780, or raloxifene (Yu et al., 2012)