how does glp 1 affect insulin secretion GLP-1 receptor signalling promotes β-cell glucose metabolism via mTOR-dependent HIF-1α activation Targeting GLP-1, GIP & GCG

Scientific reports , 10 (1), 17078

Unlike spironolactone, which is a steroidal MRA, finerenone more selectively inhibits the mineralocorticoid receptor and has limited antiandrogenic and oestrogenic effects

Nor could they rule out contamination from some other intestinal peptides that might have stimulated insulin secretion instead of GLP-1

Using two monoclonal anti-FLAG antibodies to detect the presence of the GLP-1R, we showed that the most abundant expression of GLP-1R occurs in islets, lung, and stomach ( Figures 4D and 8BC )

As GLP-1 therapies gained approval for obesity, prescribing began to diffuse beyond endocrinology into primary care, obesity medicine, and digital health platforms