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Mitochondrial dysfunction and oxidative stress in the pathogenesis of alcohol-and obesity-induced fatty liver diseases

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Taking breaks is generally not recommended because restarting requires gradual dose escalation, and intermittent use may reduce effectiveness or increase side effects

That medication-free window turned out to be an important part of this journey

[10] [11] More recently, the SELECT trial showed that Wegovy significantly reduced the risk of major adverse cardiovascular events in adults with established cardiovascular disease and overweight or obesity without diabetes, leading to an FDA-approved cardiovascular risk reduction indication