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When readers encounter bold claims about longevity peptides, asking Which rung of the ladder does this sit on? is often more useful than asking whether the molecule sounds impressive

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GLP-1 pathway Tirzepatide activates GLP-1 (glucagon-like peptide-1) receptors at about one-fifth the potency of natural GLP-1

Retatrutide is a triple receptor agonist (GIP, GLP-1, and glucagon) showing even more dramatic weight loss in early trials

British Medical Journal, 1(6073), 1390-1391