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Clinical trials show that consistent GLP-1 therapy produces 1522% body weight reduction over 68 weeks, but discontinuationoften due to costreverses these benefits within months

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Despite its clinical success, bortezomib is limited by acquired resistance and adverse effects, including peripheral neuropathy and hematologic toxicity

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6Age and Body Mass Elderly patients or those with extreme body weight (obesity or low body weight) may experience altered pharmacokinetics, increasing toxicity risk