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14 Recommendations The results above have prompted the ADA and EASD to recommend GLP-1RAs as preferred second- or third-line injectable agents following metformin in people with: 1 established atherosclerotic cardiovascular disease a need to minimise weight gain or promote weight loss a need to minimise hypoglycaemia mild-to-moderate chronic kidney disease

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Tirzepatide starts working right away in terms of affecting blood sugar and appetite, but visible changes usually take a few weeks

This can cause problems like fatigue, hair loss, or muscle weakness

If symptoms are severe, worsening, or persist beyond a couple of days, contact your healthcare provider or NHS 111 for further guidance