Experiment 3 : Cells were treated with NaB (5 mM) or vehicle for 24 h
In this Review, we evaluate the translational evidence supporting GLP-1RAs as candidate disease-modifying therapies for NDDs, describe mechanistic pathways linking metabolic dysfunction to neuronal vulnerability, and outline remaining challenges and research priorities in this rapidly evolving field
The ratio of reduced to oxidized glutathione serves as a key indicator of the cellular redox potential, with even small changes in the GSH:GSSG ratio influencing protein function by altering cysteine oxidation and disulfide bond formation (Romero-Aristizabal et al., 2014)
The therapy essentially teaches the body to avoid accumulating excess fat, creating a more sustainable environment for long-term weight management
Potthoff M, Asche N, Stein B, Muhs A, Beese F