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Critical points are represented by the actual relevance of the mucus layer covering the epithelium of the nasopharynx, by the interaction of the meningococcus with the different cell types of the human nasopharynx and the local microbiota, and by the mechanism of invasion of the epithelium (intracellular or paracellular)

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As a consequence, when estradiol levels are reduced, ROS levels increase and cause mitochondrial dysfunction

Pregnancy and breastfeeding also require stopping these medications