Trulicity should be used with caution in patients with severe gastrointestinal disease
These are observational, not causal, and they carry all the confounders of retrospective work
Case reports have also flagged associations between Melanotan 2 use and dysplastic nevus changes, defined as atypical mole development that warrants monitoring (even though causality has not been definitively established)
PlexusDx recommends that patients combining semaglutide with Synthroid request TSH and free T4 testing at baseline, then at 8-12 weeks after starting GLP-1 therapy, and again 6 months into treatment if weight loss is progressing
Within a subset of 15,237 people of European ancestry, the Nature study identified a missense variant in GLP1R, rs10305420, that was significantly associated with greater BMI loss