Importantly, 5FU-based combination treatment also shows an increase in mitochondrial mass (FOLFOX (5FU + 1 M oxaliplatin) or FOLFIRI (5FU + 5 nM SN38, active metabolite of irinotecan)) that we attribute to 5FU-imposed stress, given that single-agent oxaliplatin or SN38 do not promote the same degree of mitochondrial adaptation (Extended Data Fig
MOTS-c also improves myocardial mechanical efficiency and systolic and diastolic cardiac function, and acts centrally to improve cognitive memory function
Coca-Pelaz A, Mkitie AA, Strojan P, Corry J, Eisbruch A, Beitler JJ, Nuyts S, Smee R, Langendijk JA, Mendenhall WM, Piazza C, Rinaldo A, Ferlito A
Vitamin C, Milk Thistle, L-Cysteine, and Vitamin E are also included as supplementary ingredients
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