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Certain species within Bacteriodetes taxa, such as Bacteroides fragilis , contain lipopolysaccharide (LPS) in its outer membrane, and the toxin fragilysin, a pro-inflammatory zinc metalloprotease, can trigger systemic inflammation and amyloid fibrillogenesis (Lukiw, 2016

Leaky gut is commonly recognized in functional medicine but remains controversial in conventional medicine, which acknowledges increased intestinal permeability in conditions like celiac or Crohns disease but may not classify it as a standalone diagnosis

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