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5.4 Hyperglycemia or Hypoglycemia with Changes in Insulin Regimen Changes in insulin regimen (e.g., insulin strength, manufacturer, type, injection site or method of administration) may affect glycemic control and predispose to hypoglycemia [see Warnings and Precautions (5.6)] or hyperglycemia

Evening injections may suppress late-night appetite cravings since the medication peaks 2448 hours later, potentially during sleep and early morning

You can easily mitigate them through management

essentially, it starts running on stored energy instead of constant fuel

sIPSCs were recorded for 5 min after baseline stabilization and 8 min during GLP-1 application