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One of the peptides most intriguing roles is its impact on the hypothalamic-pituitary-adrenal (HPA) axis, where it modulates the secretion of adrenocorticotropic hormone (ACTH) and cortisol

It works by mimicking the hormone amylin, which helps regulate satiety and food intake

These molecules further activate the nuclear factor-kappa B (NF-kB) pathway, which perpetuates proinflammatory destruction in the CNS, muscle, and neuromuscular junction [237]

This is transient and will wear off after the 2 nd or 3 rd dose

Data availability Materials used to conduct this work (e.g., study manipulations, measures) and de-identified datasets are available in a public archive: References FDA