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The above study results, even so, were not significant at pH 5.5

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Do not rub the injection site, as this can alter absorption and cause irritation

A systematic review and meta-analysis of 10 randomized trials totaling 1,030 patients (Systematic review and meta-analysis: efficacy of peppermint oil in irritable bowel syndrome, Ingrosso, Ianiro, Ford and colleagues, Alimentary Pharmacology & Therapeutics , 2022) found peppermint oil superior to placebo for global IBS symptoms (number needed to treat = 4) and abdominal pain (number needed to treat = 7)

Last reviewed: June 20, 2026 Last updated: June 20, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations