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Under the pressure of dual clocks (reproductive age and metabolic age), the central challenge in management is balancing metabolic control with pregnancy safety within a finite fertility window

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Although there are no randomized controlled trials (RCTs) performed to evaluate the role of L-arginine in treatment of PD, it shows encouraging efficacy on improving the penile curvature as an agent of combination regimen in a retrospective study (Rajfer et al., 2006)