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Injection technique with 5mg vials Drawing the dose Reconstituted with 2ml water (2,500mcg/ml): 250mcg = 10 units 500mcg = 20 units Process : Wipe vial top with alcohol Draw air into syringe (same amount as dose) Inject air into vial Invert vial Draw solution slowly Remove needle, check for air bubbles Tap syringe to remove bubbles Injection sites Best locations for subcutaneous injection: Abdomen (2 inches from belly button) Front of thigh Back of upper arm (harder to self-inject) Site-specific injection (optional): Can inject near injury site for localized effect

Safety and Tolerability of Nicotinamide Riboside in Heart Failure With Reduced Ejection Fraction

J Physiol.1991;436:169193

570,571 For example, based on the unique mechanism of action of ASOs, the main safety issues are severe hepatotoxicity and nephrotoxicity caused by drug accumulation

IDA is enriched in colorectal cancer cells